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Transient Outward K+ Current (I(to)) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 1
BACKGROUND: Sudden death in long QT syndrome type 1 (LQT1), an inherited disease caused by loss-of-function mutations in KCNQ1, is triggered by early afterdepolarizations (EADs) that initiate polymorphic VT (pVT). We investigated ionic mechanisms that underlie pVT in LQT1 using a transgenic rabbit m...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Circ Arrhythm Electrophysiol |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6081959/ https://ncbi.nlm.nih.gov/pubmed/29769222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005414 |
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