Transient Outward K+ Current (I(to)) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 1

BACKGROUND: Sudden death in long QT syndrome type 1 (LQT1), an inherited disease caused by loss-of-function mutations in KCNQ1, is triggered by early afterdepolarizations (EADs) that initiate polymorphic VT (pVT). We investigated ionic mechanisms that underlie pVT in LQT1 using a transgenic rabbit m...

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Bibliografiske detaljer
Udgivet i:Circ Arrhythm Electrophysiol
Main Authors: Choi, Bum-Rak, Li, Weiyan, Terentyev, Dmitry, Kabakov, Anatoli Y., Zhong, Mingwang, Rees, Colin M, Terentyeva, Radmila, Kim, Tae Yun, Qu, Zhilin, Peng, Xuwen, Karma, Alain, Koren, Gideon
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6081959/
https://ncbi.nlm.nih.gov/pubmed/29769222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005414
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