NCX-Mediated Subcellular Ca(2+) Dynamics Underlying Early Afterdepolarizations in LQT2 Cardiomyocytes

Long QT syndrome type 2 (LQT2) is a congenital disease characterized by loss of function mutations in hERG potassium channels (I(Kr)). LQT2 is associated with fatal ventricular arrhythmias promoted by triggered activity in the form of early afterdepolarizations (EADs). We previously demonstrated tha...

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Vydáno v:Biophys J
Hlavní autoři: Zhong, Mingwang, Rees, Colin M., Terentyev, Dmitry, Choi, Bum-Rak, Koren, Gideon, Karma, Alain
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2018
Témata:
Channels and Transporters
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140381/
https://ncbi.nlm.nih.gov/pubmed/30173888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.08.004
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