NCX-Mediated Subcellular Ca(2+) Dynamics Underlying Early Afterdepolarizations in LQT2 Cardiomyocytes

Long QT syndrome type 2 (LQT2) is a congenital disease characterized by loss of function mutations in hERG potassium channels (I(Kr)). LQT2 is associated with fatal ventricular arrhythmias promoted by triggered activity in the form of early afterdepolarizations (EADs). We previously demonstrated tha...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Zhong, Mingwang, Rees, Colin M., Terentyev, Dmitry, Choi, Bum-Rak, Koren, Gideon, Karma, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2018
Assuntos:
Channels and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140381/
https://ncbi.nlm.nih.gov/pubmed/30173888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.08.004
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