Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes

We recently showed that progesterone treatment abolished arrhythmias and sudden cardiac death in a transgenic rabbit model of long QT syndrome type 2 (LQT2). Moreover, levels of cardiac sarco(endo)plasmic reticulum Ca(2+)-ATPase type 2a (SERCA2a) were upregulated in LQT2 heart extracts. We hypothesi...

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Veröffentlicht in:Am J Physiol Cell Physiol
Hauptverfasser: Moshal, Karni S., Zhang, Zhe, Roder, Karim, Kim, Tae Yun, Cooper, Leroy, Patedakis Litvinov, Bogdan, Lu, Yichun, Reddy, Vishal, Terentyev, Dmitry, Choi, Bum-Rak, Koren, Gideon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4254949/
https://ncbi.nlm.nih.gov/pubmed/25252951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00127.2014
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