Hyperphosphorylation of RyRs Underlies Triggered Activity in Transgenic Rabbit Model of LQT2 Syndrome

RATIONALE: Loss-of function mutations in HERG potassium channels underlie long QT syndrome (LQTS) type 2 (LQT2), and are associated with fatal ventricular tachyarrhythmia. Previously, most studies focused on plasmamembrane-related pathways involved in arrhythmogenesis in LQTS, while pro-arrhythmic c...

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Gepubliceerd in:Circ Res
Hoofdauteurs: Terentyev, Dmitry, Rees, Colin M., Li, Weiyan, Cooper, Leroy L., Jindal, Hitesh K., Peng, Xuwen, Lu, Yichun, Terentyeva, Radmila, Odening, Katja E., Daley, Jean, Bist, Kamana, Choi, Bum-Rak, Karma, Alain, Koren, Gideon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406222/
https://ncbi.nlm.nih.gov/pubmed/25249569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.115.305146
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