MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex

In heart failure (HF), arrhythmogenic spontaneous sarcoplasmic reticulum (SR) Ca(2+) release and afterdepolarizations in cardiac myocytes have been linked to abnormally high activity of ryanodine receptors (RyR2s) associated with enhanced phosphorylation of the channel. However, the specific molecul...

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Auteurs principaux: Belevych, Andriy E., Sansom, Sarah E., Terentyeva, Radmila, Ho, Hsiang-Ting, Nishijima, Yoshinori, Martin, Mickey M., Jindal, Hitesh K., Rochira, Jennifer A., Kunitomo, Yukiko, Abdellatif, Maha, Carnes, Cynthia A., Elton, Terry S., Györke, Sandor, Terentyev, Dmitry
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3232211/
https://ncbi.nlm.nih.gov/pubmed/22163007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028324
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