MiR-1 Overexpression Enhances Ca(2+) release and Promotes Cardiac Arrhythmogenesis by Targeting PP2A Regulatory Subunit B56α and Causing CaMKII-Dependent Hyperphosphorylation of RyR2

MicroRNAs are small endogenous noncoding RNAs that regulate protein expression by hybridization to imprecise complementary sequences of target mRNAs. Changes in abundance of muscle-specific microRNA, miR-1, have been implicated in cardiac disease, including arrhythmia and heart failure. However, the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Terentyev, Dmitry, Belevych, Andriy E., Terentyeva, Radmila, Martin, Mickey M., Malana, Geraldine E., Kuhn, Donald E., Abdellatif, Maha, Feldman, David S, Elton, Terry S., Gyorke, Sandor
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394868/
https://ncbi.nlm.nih.gov/pubmed/19131648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.181651
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados