MiR-1 Overexpression Enhances Ca(2+) release and Promotes Cardiac Arrhythmogenesis by Targeting PP2A Regulatory Subunit B56α and Causing CaMKII-Dependent Hyperphosphorylation of RyR2

MicroRNAs are small endogenous noncoding RNAs that regulate protein expression by hybridization to imprecise complementary sequences of target mRNAs. Changes in abundance of muscle-specific microRNA, miR-1, have been implicated in cardiac disease, including arrhythmia and heart failure. However, the...

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Veröffentlicht in:Circ Res
Hauptverfasser: Terentyev, Dmitry, Belevych, Andriy E., Terentyeva, Radmila, Martin, Mickey M., Malana, Geraldine E., Kuhn, Donald E., Abdellatif, Maha, Feldman, David S, Elton, Terry S., Gyorke, Sandor
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394868/
https://ncbi.nlm.nih.gov/pubmed/19131648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.181651
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