Increased RyR2 activity is exacerbated by calcium leak-induced mitochondrial ROS

Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic reticulum (SR) Ca(2+) release channel, the ryanodine receptor (RyR2). The transfer of Ca(2+) from the SR via RyR2 to mitochondri...

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Detalhes bibliográficos
Publicado no:Basic Res Cardiol
Main Authors: Hamilton, Shanna, Terentyeva, Radmila, Martin, Benjamin, Perger, Fruzsina, Li, Jiaoni, Stepanov, Andrei, Bonilla, Ingrid M., Knollmann, Björn C., Radwański, Przemyslaw B., Györke, Sandor, Belevych, Andriy E., Terentyev, Dmitry
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
Assuntos:
Original Contribution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7244455/
https://ncbi.nlm.nih.gov/pubmed/32444920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-020-0797-z
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