Sarcoplasmic reticulum Ca(2+) release is both necessary and sufficient for SK channel activation in ventricular myocytes

SK channels are upregulated in human patients and animal models of heart failure (HF). However, their activation mechanism and function in ventricular myocytes remain poorly understood. We aim to test the hypotheses that activation of SK channels in ventricular myocytes requires Ca(2+) release from...

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Bibliographic Details
Main Authors: Terentyev, Dmitry, Rochira, Jennifer A., Terentyeva, Radmila, Roder, Karim, Koren, Gideon, Li, Weiyan
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
Subjects:
Cardiac Excitation and Contraction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949063/
https://ncbi.nlm.nih.gov/pubmed/24381116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00621.2013
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