Sarcoplasmic reticulum Ca(2+) release is both necessary and sufficient for SK channel activation in ventricular myocytes

SK channels are upregulated in human patients and animal models of heart failure (HF). However, their activation mechanism and function in ventricular myocytes remain poorly understood. We aim to test the hypotheses that activation of SK channels in ventricular myocytes requires Ca(2+) release from...

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Detalhes bibliográficos
Main Authors: Terentyev, Dmitry, Rochira, Jennifer A., Terentyeva, Radmila, Roder, Karim, Koren, Gideon, Li, Weiyan
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
Assuntos:
Cardiac Excitation and Contraction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949063/
https://ncbi.nlm.nih.gov/pubmed/24381116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00621.2013
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