PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts

KEY POINTS: Small‐conductance Ca(2+)‐activated K(+) (SK) channels expressed in ventricular myocytes are dormant in health, yet become functional in cardiac disease. SK channels are voltage independent and their gating is controlled by intracellular [Ca(2+)] in a biphasic manner. Submicromolar [Ca(2+...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Physiol
Auteurs principaux: Hamilton, Shanna, Polina, Iuliia, Terentyeva, Radmila, Bronk, Peter, Kim, Tae Yun, Roder, Karim, Clements, Richard T., Koren, Gideon, Choi, Bum‐Rak, Terentyev, Dmitry
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2019
Sujets:
Aberrant Calcium Signaling and Arrhythmia Mechanisms
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7496687/
https://ncbi.nlm.nih.gov/pubmed/30771223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277618
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