Pharmacological Modulation of Mitochondrial Ca(2+) Content Regulates Sarcoplasmic Reticulum Ca(2+) Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species

In a physiological setting, mitochondria increase oxidative phosphorylation during periods of stress to meet increased metabolic demand. This in part is mediated via enhanced mitochondrial Ca(2+) uptake, an important regulator of cellular ATP homeostasis. In a pathophysiological setting pharmacologi...

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Detalhes bibliográficos
Publicado no:Front Physiol
Main Authors: Hamilton, Shanna, Terentyeva, Radmila, Kim, Tae Yun, Bronk, Peter, Clements, Richard T., O-Uchi, Jin, Csordás, György, Choi, Bum-Rak, Terentyev, Dmitry
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Physiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6308295/
https://ncbi.nlm.nih.gov/pubmed/30622478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2018.01831
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