Prospective analysis of adoptive TIL therapy in patients with metastatic melanoma: response, impact of anti-CTLA4, and biomarkers to predict clinical outcome

PURPOSE: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) has consistently demonstrated clinical efficacy in metastatic melanoma. Recent widespread use of checkpoint blockade has shifted the treatment landscape, raising questions regarding impact of these therapies on response...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Forget, Marie-Andrée, Haymaker, Cara, Hess, Kenneth R., Meng, Yuzhong Jeff, Creasy, Caitlin, Karpinets, Tatiana, Fulbright, Orenthial J., Roszik, Jason, Woodman, Scott E., Kim, Young Uk, Sakellariou-Thompson, Donastas, Bhatta, Ankit, Wahl, Arely, Flores, Esteban, Thorsen, Shawne T., Tavera, René J., Ramachandran, Renjith, Gonzalez, Audrey M., Toth, Christopher L., Wardell, Seth, Mansaray, Rahmatu, Patel, Vruti, Carpio, Destiny Joy, Vaughn, Carol, Farinas, Chantell M., Velasquez, Portia G., Hwu, Wen-Jen, Patel, Sapna P., Davies, Michael A., Diab, Adi, Glitza, Isabella C., Tawbi, Hussein, Wong, Michael K., Cain, Suzanne, Ross, Merrick I., Lee, Jeffrey E., Gershenwald, Jeffrey E., Lucci, Anthony, Royal, Richard, Cormier, Janice N., Wargo, Jennifer A., Radvanyi, Laszlo G., Torres-Cabala, Carlos A., Beroukhim, Rameen, Hwu, Patrick, Amaria, Rodabe N., Bernatchez, Chantale
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139043/
https://ncbi.nlm.nih.gov/pubmed/29848573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3649
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