Prospective analysis of adoptive TIL therapy in patients with metastatic melanoma: response, impact of anti-CTLA4, and biomarkers to predict clinical outcome

PURPOSE: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) has consistently demonstrated clinical efficacy in metastatic melanoma. Recent widespread use of checkpoint blockade has shifted the treatment landscape, raising questions regarding impact of these therapies on response...

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Udgivet i:Clin Cancer Res
Main Authors: Forget, Marie-Andrée, Haymaker, Cara, Hess, Kenneth R., Meng, Yuzhong Jeff, Creasy, Caitlin, Karpinets, Tatiana, Fulbright, Orenthial J., Roszik, Jason, Woodman, Scott E., Kim, Young Uk, Sakellariou-Thompson, Donastas, Bhatta, Ankit, Wahl, Arely, Flores, Esteban, Thorsen, Shawne T., Tavera, René J., Ramachandran, Renjith, Gonzalez, Audrey M., Toth, Christopher L., Wardell, Seth, Mansaray, Rahmatu, Patel, Vruti, Carpio, Destiny Joy, Vaughn, Carol, Farinas, Chantell M., Velasquez, Portia G., Hwu, Wen-Jen, Patel, Sapna P., Davies, Michael A., Diab, Adi, Glitza, Isabella C., Tawbi, Hussein, Wong, Michael K., Cain, Suzanne, Ross, Merrick I., Lee, Jeffrey E., Gershenwald, Jeffrey E., Lucci, Anthony, Royal, Richard, Cormier, Janice N., Wargo, Jennifer A., Radvanyi, Laszlo G., Torres-Cabala, Carlos A., Beroukhim, Rameen, Hwu, Patrick, Amaria, Rodabe N., Bernatchez, Chantale
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139043/
https://ncbi.nlm.nih.gov/pubmed/29848573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3649
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