Prospective analysis of adoptive TIL therapy in patients with metastatic melanoma: response, impact of anti-CTLA4, and biomarkers to predict clinical outcome

PURPOSE: Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) has consistently demonstrated clinical efficacy in metastatic melanoma. Recent widespread use of checkpoint blockade has shifted the treatment landscape, raising questions regarding impact of these therapies on response...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Forget, Marie-Andrée, Haymaker, Cara, Hess, Kenneth R., Meng, Yuzhong Jeff, Creasy, Caitlin, Karpinets, Tatiana, Fulbright, Orenthial J., Roszik, Jason, Woodman, Scott E., Kim, Young Uk, Sakellariou-Thompson, Donastas, Bhatta, Ankit, Wahl, Arely, Flores, Esteban, Thorsen, Shawne T., Tavera, René J., Ramachandran, Renjith, Gonzalez, Audrey M., Toth, Christopher L., Wardell, Seth, Mansaray, Rahmatu, Patel, Vruti, Carpio, Destiny Joy, Vaughn, Carol, Farinas, Chantell M., Velasquez, Portia G., Hwu, Wen-Jen, Patel, Sapna P., Davies, Michael A., Diab, Adi, Glitza, Isabella C., Tawbi, Hussein, Wong, Michael K., Cain, Suzanne, Ross, Merrick I., Lee, Jeffrey E., Gershenwald, Jeffrey E., Lucci, Anthony, Royal, Richard, Cormier, Janice N., Wargo, Jennifer A., Radvanyi, Laszlo G., Torres-Cabala, Carlos A., Beroukhim, Rameen, Hwu, Patrick, Amaria, Rodabe N., Bernatchez, Chantale
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6139043/
https://ncbi.nlm.nih.gov/pubmed/29848573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3649
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