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Targeting HPV16 DNA using CRISPR/Cas inhibits anal cancer growth in vivo
AIM: The goal of this study was to determine if a single AAV vector, encoding Cas9 and guide RNAs specific for the HPV16 E6 and E7 genes, could inhibit the growth of an HPV16-induced tumor in vivo. MATERIALS & METHODS: We grew HPV16(+), patient-derived anal cancer explants in immunodeficient mic...
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| Pubblicato in: | Future Virol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Future Medicine Ltd
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6136077/ https://ncbi.nlm.nih.gov/pubmed/30245733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fvl-2018-0010 |
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