Targeting HPV16 DNA using CRISPR/Cas inhibits anal cancer growth in vivo

AIM: The goal of this study was to determine if a single AAV vector, encoding Cas9 and guide RNAs specific for the HPV16 E6 and E7 genes, could inhibit the growth of an HPV16-induced tumor in vivo. MATERIALS & METHODS: We grew HPV16(+), patient-derived anal cancer explants in immunodeficient mic...

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Bibliografiske detaljer
Udgivet i:Future Virol
Main Authors: Hsu, David S, Kornepati, Anand VR, Glover, Wayne, Kennedy, Edward M, Cullen, Bryan R
Format: Artigo
Sprog:Inglês
Udgivet: Future Medicine Ltd 2018
Fag:
Short Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136077/
https://ncbi.nlm.nih.gov/pubmed/30245733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fvl-2018-0010
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