Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease

Hepatitis B virus (HBV) remains a major human pathogen, with over 240 million individuals suffering from chronic HBV infections. These can persist for decades due to the lack of therapies that can effectively target the stable viral covalently closed circular (ccc) DNA molecules present in infected...

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Vydáno v:Virology
Hlavní autoři: Kennedy, Edward M., Bassit, Leda C., Mueller, Henrik, Kornepati, Anand V. R., Bogerd, Hal P., Nie, Ting, Chatterjee, Payel, Javanbakht, Hassan, Schinazi, Raymond F., Cullen, Bryan R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4323668/
https://ncbi.nlm.nih.gov/pubmed/25553515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.12.001
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