Optimization of a multiplex CRISPR/Cas system for use as an antiviral therapeutic

RNA-guided endonucleases or CRISPR/Cas systems have been widely employed for gene engineering/DNA editing applications, and have recently been used against a variety of dsDNA viruses as a potential therapeutic. However, in vivo delivery to specific tissue reservoirs using adeno-associated virus (AAV...

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Библиографические подробности
Опубликовано в: :Methods
Главные авторы: Kennedy, Edward M., Kornepati, Anand V. R., Mefferd, Adam L., Marshall, Joy B., Tsai, Kevin, Bogerd, Hal P., Cullen, Bryan R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684739/
https://ncbi.nlm.nih.gov/pubmed/26291065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2015.08.012
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