Inactivation of the Human Papillomavirus E6 or E7 Gene in Cervical Carcinoma Cells by Using a Bacterial CRISPR/Cas RNA-Guided Endonuclease

High-risk human papillomaviruses (HPVs), including HPV-16 and HPV-18, are the causative agents of cervical carcinomas and are linked to several other tumors of the anogenital and oropharyngeal regions. The majority of HPV-induced tumors contain integrated copies of the normally episomal HPV genome t...

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Main Authors: Kennedy, Edward M., Kornepati, Anand V. R., Goldstein, Michael, Bogerd, Hal P., Poling, Brigid C., Whisnant, Adam W., Kastan, Michael B., Cullen, Bryan R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4178730/
https://ncbi.nlm.nih.gov/pubmed/25100830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01879-14
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