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Specific induction of endogenous viral restriction factors using CRISPR/Cas-derived transcriptional activators

Whereas several mammalian proteins can restrict the replication of HIV-1 and other viruses, these are often not expressed in relevant target cells. A potential method to inhibit viral replication might therefore be to use synthetic transcription factors to induce restriction factor expression. In pa...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Bogerd, Hal P., Kornepati, Anand V. R., Marshall, Joy B., Kennedy, Edward M., Cullen, Bryan R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703010/
https://ncbi.nlm.nih.gov/pubmed/26668372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516305112
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