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Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer

Although RNA interference (RNAi) functions as a potent antiviral innate-immune response in plants and invertebrates, mammalian somatic cells appear incapable of mounting an RNAi response and few, if any, small interfering RNAs (siRNAs) can be detected. To examine why siRNA production is inefficient,...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Kennedy, Edward M., Whisnant, Adam W., Kornepati, Anand V. R., Marshall, Joy B., Bogerd, Hal P., Cullen, Bryan R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687602/
https://ncbi.nlm.nih.gov/pubmed/26621737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513421112
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