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Production of functional small interfering RNAs by an amino-terminal deletion mutant of human Dicer
Although RNA interference (RNAi) functions as a potent antiviral innate-immune response in plants and invertebrates, mammalian somatic cells appear incapable of mounting an RNAi response and few, if any, small interfering RNAs (siRNAs) can be detected. To examine why siRNA production is inefficient,...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4687602/ https://ncbi.nlm.nih.gov/pubmed/26621737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513421112 |
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