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Design, data monitoring and analysis of clinical trials with co-primary endpoints: a review

We review the design, data monitoring, and analyses of clinical trials with co-primary endpoints. Recently developed methods for fixed-sample and group-sequential settings are described. Practical considerations are discussed and guidance for the application of these methods is provided.

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Detalhes bibliográficos
Publicado no:J Biopharm Stat
Main Authors: Hamasaki, Toshimitsu, Evans, Scott R., Asakura, Koko
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135538/
https://ncbi.nlm.nih.gov/pubmed/29083951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2017.1378668
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