Clinicopathologic Features of Non–Small-Cell Lung Cancer Harboring an NTRK Gene Fusion

PURPOSE: Gene rearrangements that involve NTRK1/2/3 can generate fusion oncoproteins that contain the kinase domains of TRKA/B/C, respectively. These fusions are rare in non–small-cell lung cancer (NSCLC), with frequency previously estimated to be < 1%. Inhibition of TRK signaling has led to dram...

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Bibliografske podrobnosti
izdano v:JCO Precis Oncol
Main Authors: Farago, Anna F., Taylor, Martin S., Doebele, Robert C., Zhu, Viola W., Kummar, Shivaani, Spira, Alexander I., Boyle, Theresa A., Haura, Eric B., Arcila, Maria E., Benayed, Ryma, Aisner, Dara L., Horick, Nora K., Lennerz, Jochen K., Le, Long P., Iafrate, A. John, Ou, Sai-Hong I., Shaw, Alice T., Mino-Kenudson, Mari, Drilon, Alexander
Format: Artigo
Jezik:Inglês
Izdano: American Society of Clinical Oncology 2018
Teme:
Original Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132056/
https://ncbi.nlm.nih.gov/pubmed/30215037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00037
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