Clinicopathologic Features of Non–Small-Cell Lung Cancer Harboring an NTRK Gene Fusion

PURPOSE: Gene rearrangements that involve NTRK1/2/3 can generate fusion oncoproteins that contain the kinase domains of TRKA/B/C, respectively. These fusions are rare in non–small-cell lung cancer (NSCLC), with frequency previously estimated to be < 1%. Inhibition of TRK signaling has led to dram...

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Detalles Bibliográficos
Publicado en:JCO Precis Oncol
Main Authors: Farago, Anna F., Taylor, Martin S., Doebele, Robert C., Zhu, Viola W., Kummar, Shivaani, Spira, Alexander I., Boyle, Theresa A., Haura, Eric B., Arcila, Maria E., Benayed, Ryma, Aisner, Dara L., Horick, Nora K., Lennerz, Jochen K., Le, Long P., Iafrate, A. John, Ou, Sai-Hong I., Shaw, Alice T., Mino-Kenudson, Mari, Drilon, Alexander
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Clinical Oncology 2018
Assuntos:
Original Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132056/
https://ncbi.nlm.nih.gov/pubmed/30215037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00037
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