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NTRK fusion-positive cancers and TRK inhibitor therapy
NTRK gene fusions involving either NTRK1, NTRK2, or NTRK3 (encoding the neurotrophin receptors TRKA, TRKB, and TRKC, respectively) are oncogenic drivers of various adult and paediatric tumour types. These fusions can be detected in the clinic using a variety of methods, including tumour DNA and RNA...
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| Veröffentlicht in: | Nat Rev Clin Oncol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6419506/ https://ncbi.nlm.nih.gov/pubmed/30333516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41571-018-0113-0 |
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