Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers

Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the neurotrophic receptor tyrosine kinase 1, 2 and 3 (NTRK1, NTRK2 and NTRK3) genes, respectively. TRKs can regulate cell proliferation...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Jiang, Tingting, Wang, Guan, Liu, Yao, Feng, Lu, Wang, Meng, Liu, Jie, Chen, Yi, Ouyang, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893124/
https://ncbi.nlm.nih.gov/pubmed/33643817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.05.004
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