Clinicopathologic Features of Non–Small-Cell Lung Cancer Harboring an NTRK Gene Fusion

PURPOSE: Gene rearrangements that involve NTRK1/2/3 can generate fusion oncoproteins that contain the kinase domains of TRKA/B/C, respectively. These fusions are rare in non–small-cell lung cancer (NSCLC), with frequency previously estimated to be < 1%. Inhibition of TRK signaling has led to dram...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:JCO Precis Oncol
Main Authors: Farago, Anna F., Taylor, Martin S., Doebele, Robert C., Zhu, Viola W., Kummar, Shivaani, Spira, Alexander I., Boyle, Theresa A., Haura, Eric B., Arcila, Maria E., Benayed, Ryma, Aisner, Dara L., Horick, Nora K., Lennerz, Jochen K., Le, Long P., Iafrate, A. John, Ou, Sai-Hong I., Shaw, Alice T., Mino-Kenudson, Mari, Drilon, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2018
Fag:
Original Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132056/
https://ncbi.nlm.nih.gov/pubmed/30215037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00037
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker