Clinicopathologic Features of Non–Small-Cell Lung Cancer Harboring an NTRK Gene Fusion

PURPOSE: Gene rearrangements that involve NTRK1/2/3 can generate fusion oncoproteins that contain the kinase domains of TRKA/B/C, respectively. These fusions are rare in non–small-cell lung cancer (NSCLC), with frequency previously estimated to be < 1%. Inhibition of TRK signaling has led to dram...

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Bibliografiset tiedot
Julkaisussa:JCO Precis Oncol
Päätekijät: Farago, Anna F., Taylor, Martin S., Doebele, Robert C., Zhu, Viola W., Kummar, Shivaani, Spira, Alexander I., Boyle, Theresa A., Haura, Eric B., Arcila, Maria E., Benayed, Ryma, Aisner, Dara L., Horick, Nora K., Lennerz, Jochen K., Le, Long P., Iafrate, A. John, Ou, Sai-Hong I., Shaw, Alice T., Mino-Kenudson, Mari, Drilon, Alexander
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Clinical Oncology 2018
Aiheet:
Original Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132056/
https://ncbi.nlm.nih.gov/pubmed/30215037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00037
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