Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool. We have discovered ascofuranone (1), a natural compound p...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Miyazaki, Yukiko, Inaoka, Daniel K., Shiba, Tomoo, Saimoto, Hiroyuki, Sakura, Takaya, Amalia, Eri, Kido, Yasutoshi, Sakai, Chika, Nakamura, Mari, Moore, Anthony L., Harada, Shigeharu, Kita, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131557/
https://ncbi.nlm.nih.gov/pubmed/30233375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00997
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