Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool. We have discovered ascofuranone (1), a natural compound p...

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Библиографические подробности
Опубликовано в: :Front Pharmacol
Главные авторы: Miyazaki, Yukiko, Inaoka, Daniel K., Shiba, Tomoo, Saimoto, Hiroyuki, Sakura, Takaya, Amalia, Eri, Kido, Yasutoshi, Sakai, Chika, Nakamura, Mari, Moore, Anthony L., Harada, Shigeharu, Kita, Kiyoshi
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2018
Предметы:
Pharmacology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131557/
https://ncbi.nlm.nih.gov/pubmed/30233375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00997
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