Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool. We have discovered ascofuranone (1), a natural compound p...

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Veröffentlicht in:Front Pharmacol
Hauptverfasser: Miyazaki, Yukiko, Inaoka, Daniel K., Shiba, Tomoo, Saimoto, Hiroyuki, Sakura, Takaya, Amalia, Eri, Kido, Yasutoshi, Sakai, Chika, Nakamura, Mari, Moore, Anthony L., Harada, Shigeharu, Kita, Kiyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131557/
https://ncbi.nlm.nih.gov/pubmed/30233375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00997
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