Identification of 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

Plasmodium falciparum’s resistance to available antimalarial drugs highlights the need for the development of novel drugs. Pyrimidine de novo biosynthesis is a validated drug target for the prevention and treatment of malaria infection. P. falciparum dihydroorotate dehydrogenase (PfDHODH) catalyzes...

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Publicado no:Int J Mol Sci
Main Authors: Hartuti, Endah Dwi, Sakura, Takaya, Tagod, Mohammed S. O., Yoshida, Eri, Wang, Xinying, Mochizuki, Kota, Acharjee, Rajib, Matsuo, Yuichi, Tokumasu, Fuyuki, Mori, Mihoko, Waluyo, Danang, Shiomi, Kazuro, Nozaki, Tomoyoshi, Hamano, Shinjiro, Shiba, Tomoo, Kita, Kiyoshi, Inaoka, Daniel Ken
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8268581/
https://ncbi.nlm.nih.gov/pubmed/34281290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22137236
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