ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes

The HMG-CoA reductase degradation protein 1 (HRD1) has been identified as a key enzyme for endoplasmic reticulum-associated degradation of misfolded proteins, but its organ-specific physiological functions remain largely undefined. Here we show that mice with HRD1 deletion specifically in the liver...

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Pubblicato in:Nat Commun
Autori principali: Wei, Juncheng, Yuan, Yanzhi, Chen, Lu, Xu, Yuanming, Zhang, Yuehui, Wang, Yajun, Yang, Yanjie, Peek, Clara Bien, Diebold, Lauren, Yang, Yi, Gao, Beixue, Jin, Chaozhi, Melo-Cardenas, Johanna, Chandel, Navdeep S., Zhang, Donna D., Pan, Hui, Zhang, Kezhong, Wang, Jian, He, Fuchu, Fang, Deyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131148/
https://ncbi.nlm.nih.gov/pubmed/30201971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06091-7
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