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HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination
The endoplasmic reticulum‐associated protein degradation (ERAD) is responsible for recognizing and retro‐translocating protein substrates, misfolded or not, from the ER for cytosolic proteasomal degradation. HMG‐CoA Reductase (HMGCR) Degradation protein—HRD1—was initially identified as an E3 ligase...
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| Publicado no: | EMBO J |
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| Main Authors: | , , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6236336/ https://ncbi.nlm.nih.gov/pubmed/30389664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201898942 |
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