HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination

The endoplasmic reticulum‐associated protein degradation (ERAD) is responsible for recognizing and retro‐translocating protein substrates, misfolded or not, from the ER for cytosolic proteasomal degradation. HMG‐CoA Reductase (HMGCR) Degradation protein—HRD1—was initially identified as an E3 ligase...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Wei, Juncheng, Chen, Lu, Li, Fei, Yuan, Yanzhi, Wang, Yajun, Xia, Wanjun, Zhang, Yuehui, Xu, Yuanming, Yang, Zhao, Gao, Beixue, Jin, Chaozhi, Melo‐Cardenas, Johanna, Green, Richard M, Pan, Hui, Wang, Jian, He, Fuchu, Zhang, Kezhong, Fang, Deyu
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236336/
https://ncbi.nlm.nih.gov/pubmed/30389664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201898942
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