HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination

The endoplasmic reticulum‐associated protein degradation (ERAD) is responsible for recognizing and retro‐translocating protein substrates, misfolded or not, from the ER for cytosolic proteasomal degradation. HMG‐CoA Reductase (HMGCR) Degradation protein—HRD1—was initially identified as an E3 ligase...

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Библиографические подробности
Опубликовано в: :EMBO J
Главные авторы: Wei, Juncheng, Chen, Lu, Li, Fei, Yuan, Yanzhi, Wang, Yajun, Xia, Wanjun, Zhang, Yuehui, Xu, Yuanming, Yang, Zhao, Gao, Beixue, Jin, Chaozhi, Melo‐Cardenas, Johanna, Green, Richard M, Pan, Hui, Wang, Jian, He, Fuchu, Zhang, Kezhong, Fang, Deyu
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2018
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236336/
https://ncbi.nlm.nih.gov/pubmed/30389664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201898942
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