HRD1‐ERAD controls production of the hepatokine FGF21 through CREBH polyubiquitination

The endoplasmic reticulum‐associated protein degradation (ERAD) is responsible for recognizing and retro‐translocating protein substrates, misfolded or not, from the ER for cytosolic proteasomal degradation. HMG‐CoA Reductase (HMGCR) Degradation protein—HRD1—was initially identified as an E3 ligase...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Wei, Juncheng, Chen, Lu, Li, Fei, Yuan, Yanzhi, Wang, Yajun, Xia, Wanjun, Zhang, Yuehui, Xu, Yuanming, Yang, Zhao, Gao, Beixue, Jin, Chaozhi, Melo‐Cardenas, Johanna, Green, Richard M, Pan, Hui, Wang, Jian, He, Fuchu, Zhang, Kezhong, Fang, Deyu
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236336/
https://ncbi.nlm.nih.gov/pubmed/30389664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201898942
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