Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program

OBJECTIVE: The endoplasmic reticulum (ER)-resident E3 ligase HRD1 and its co-activator Sel1L are major components of ER-associated degradation (ERAD) machinery. Here, we investigated the molecular mechanism and functional significance underlying the circadian regulation of HRD1/Sel1L-mediated protei...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Metab
Prif Awduron: Kim, Hyunbae, Wei, Juncheng, Song, Zhenfeng, Mottillo, Emilio, Samavati, Lobelia, Zhang, Ren, Li, Li, Chen, Xuequn, Jena, Bhanu P., Lin, Jiandie D., Fang, Deyu, Zhang, Kezhong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2021
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7966871/
https://ncbi.nlm.nih.gov/pubmed/33592335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2021.101192
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