Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas

Humoral immunity involves multiple checkpoints during B-cell development, maturation, and activation. The cell death receptor CD95/Fas-mediated apoptosis plays a critical role in eliminating the unwanted activation of B cells by self-reactive antigens and in maintaining B-cell homeostasis through ac...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kong, Sinyi, Yang, Yi, Xu, Yuanming, Wang, Yajun, Zhang, Yusi, Melo-Cardenas, Johanna, Xu, Xiangping, Gao, Beixue, Thorp, Edward B., Zhang, Donna D., Zhang, Bin, Song, Jianxun, Zhang, Kezhong, Zhang, Jianning, Zhang, Jinping, Li, Huabin, Fang, Deyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027446/
https://ncbi.nlm.nih.gov/pubmed/27573825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606742113
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