The endoplasmic reticulum–resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice

Humoral immunity involves multiple checkpoints that occur in B cell development, maturation, and activation. The pre–B-cell receptor (pre-BCR) is expressed following the productive recombination of the immunoglobulin heavy-chain gene, and sSignalsing through the pre-BCR are required for the differen...

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Udgivet i:J Biol Chem
Main Authors: Yang, Yi, Kong, Sinyi, Zhang, Yana, Melo-Cardenas, Johanna, Gao, Beixue, Zhang, Yusi, Zhang, Donna D., Zhang, Bin, Song, Jianxun, Thorp, Edward, Zhang, Kezhong, Zhang, Jinping, Fang, Deyu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6102136/
https://ncbi.nlm.nih.gov/pubmed/29907570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001267
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