Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation†

Hypoxia in solid tumors remains a challenge for conventional cancer therapeutics. As a source for resistance, metastasis development and drug bioprocessing, it influences treatment results and disease outcome. Bioreductive platinum(iv) prodrugs might be advantageous over conventional metal-based the...

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Publicat a:Metallomics
Autors principals: Schreiber-Brynzak, Ekaterina, Pichler, Verena, Heffeter, Petra, Hanson, Buck, Theiner, Sarah, Lichtscheidl-Schultz, Irene, Kornauth, Christoph, Bamonti, Luca, Dhery, Vineet, Groza, Diana, Berry, David, Berger, Walter, Galanski, Markus, Jakupec, Michael A., Keppler, Bernhard K.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130773/
https://ncbi.nlm.nih.gov/pubmed/26860208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5mt00312a
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