Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application

Platinum(IV) complexes are promising candidates as prodrugs for oral application in anticancer chemotherapy. However, only a few Pt(IV) compounds entered (pre)clinical trials, e.g. satraplatin, while most of the others were only tested in vitro. Aim of the study was investigation of the in vivo phar...

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Detalhes bibliográficos
Publicado no:J Biol Inorg Chem
Main Authors: Theiner, Sarah, Varbanov, Hristo P., Galanski, Mathea Sophia, Egger, Alexander E., Berger, Walter, Heffeter, Petra, Keppler, Bernhard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351919/
https://ncbi.nlm.nih.gov/pubmed/25413442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-014-1214-6
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