Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application

Platinum(IV) complexes are promising candidates as prodrugs for oral application in anticancer chemotherapy. However, only a few Pt(IV) compounds entered (pre)clinical trials, e.g. satraplatin, while most of the others were only tested in vitro. Aim of the study was investigation of the in vivo phar...

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Veröffentlicht in:J Biol Inorg Chem
Hauptverfasser: Theiner, Sarah, Varbanov, Hristo P., Galanski, Mathea Sophia, Egger, Alexander E., Berger, Walter, Heffeter, Petra, Keppler, Bernhard K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351919/
https://ncbi.nlm.nih.gov/pubmed/25413442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-014-1214-6
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