A Novel Class of Bis- and Tris-Chelate Diam(m)inebis(dicarboxylato)platinum(IV) Complexes as Potential Anticancer Prodrugs

A novel class of platinum(IV) complexes of the type [Pt(Am)-(R(COO)(2))(2)], where Am is a chelating diamine or two monodentate am(m)ine ligands and R(COO)(2) is a chelating dicarboxylato moiety, was synthesized. For this purpose, the reaction between the corresponding tetrahydroxidoplatinum(IV) pre...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Varbanov, Hristo P., Göschl, Simone, Heffeter, Petra, Theiner, Sarah, Roller, Alexander, Jensen, Frank, Jakupec, Michael A., Berger, Walter, Galanski, Markus, Keppler, Bernhard K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351917/
https://ncbi.nlm.nih.gov/pubmed/25032896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500791c
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