Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(iv)-based anticancer agents†

The selection of drug candidates for entering clinical development relies on in vivo testing in (solid) tumor animal models. However, the heterogeneity of tumor tissue (e.g. in terms of drug uptake or tissue composition) is rarely considered when testing novel drug candidates. Therefore, we used the...

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Bibliographic Details
Published in:Metallomics
Main Authors: Theiner, Sarah, Kornauth, Christoph, Varbanov, Hristo P., Galanski, Markus, Van Schoonhoven, Sushilla, Heffeter, Petra, Berger, Walter, Egger, Alexander E., Keppler, Bernhard K.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130778/
https://ncbi.nlm.nih.gov/pubmed/25856224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5mt00028a
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