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TET family dioxygenases and DNA demethylation in stem cells and cancers

The methylation of cytosine and subsequent oxidation constitutes a fundamental epigenetic modification in mammalian genomes, and its abnormalities are intimately coupled to various pathogenic processes including cancer development. Enzymes of the Ten–eleven translocation (TET) family catalyze the st...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: An, Jungeun, Rao, Anjana, Ko, Myunggon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130217/
https://ncbi.nlm.nih.gov/pubmed/28450733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.5
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