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TET family dioxygenases and the TET activator vitamin C in immune responses and cancer
Vitamin C serves as a cofactor for Fe(II) and 2-oxoglutarate–dependent dioxygenases including TET family enzymes, which catalyze the oxidation of 5-methylcytosine into 5-hydroxymethylcytosine and further oxidize methylcytosines. Loss-of-function mutations in epigenetic regulators such as TET genes a...
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| Veröffentlicht in: | Blood |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7498365/ https://ncbi.nlm.nih.gov/pubmed/32730592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004158 |
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