The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

Epigenetic regulation of lineage-specific genes is important for the differentiation and function of T cell. Ten-eleven translocation (Tet) proteins catalyze 5-methylcytosine (5mC) conversion to 5-hydroxymethylcytosine (5hmC) to mediate DNA demethylation. However, the roles of Tet proteins in the im...

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Publicado no:Immunity
Main Authors: Ichiyama, Kenji, Chen, Tingting, Wang, Xiaohu, Yan, Xiaowei, Kim, Byung-Seok, Tanaka, Shinya, Ndiaye-Lobry, Delphine, Deng, Yuhua, Zou, Yanli, Zheng, Pan, Tian, Qiang, Aifantis, Iannis, Wei, Lai, Dong, Chen
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956728/
https://ncbi.nlm.nih.gov/pubmed/25862091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.03.005
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