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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain

Cytosine methylation is the major covalent modification of mammalian genomic DNA and plays important roles in transcriptional regulation. The molecular mechanism underlying the enzymatic removal of this epigenetic mark, however, remains elusive. Here we show that 5-methylcytosine (5mC) hydroxylase T...

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Autores principales: Guo, Junjie U., Su, Yijing, Zhong, Chun, Ming, Guo-li, Song, Hongjun
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088758/
https://ncbi.nlm.nih.gov/pubmed/21496894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.022
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