Quantitative assessment of Tet-induced oxidation products of 5-methylcytosine in cellular and tissue DNA

Recent studies showed that Ten-eleven translocation (Tet) family dioxygenases can oxidize 5-methyl-2’-deoxycytidine (5-mdC) in DNA to yield the 5-hydroxymethyl, 5-formyl and 5-carboxyl derivatives of 2’-deoxycytidine (5-HmdC, 5-FodC and 5-CadC). 5-HmdC in DNA may be enzymatically deaminated to yield...

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Detalhes bibliográficos
Main Authors: Liu, Shuo, Wang, Jin, Su, Yijing, Guerrero, Candace, Zeng, Yaxue, Mitra, Devarati, Brooks, Philip J., Fisher, David E., Song, Hongjun, Wang, Yinsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711458/
https://ncbi.nlm.nih.gov/pubmed/23658232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt360
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