Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea

TET/JBP enzymes oxidize 5-methylpyrimidines in DNA. In mammals, the oxidized methylcytosines (oxi-mCs) function as epigenetic marks and likely intermediates in DNA demethylation. Here we present a method based on diglucosylation of 5-hydroxymethylcytosine (5hmC) to simultaneously map 5hmC, 5-formylc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chavez, Lukas, Huang, Yun, Luong, Khai, Agarwal, Suneet, Iyer, Lakshminarayan M., Pastor, William A., Hench, Virginia K., Frazier-Bowers, Sylvia A., Korol, Evgenia, Liu, Shuo, Tahiliani, Mamta, Wang, Yinsheng, Clark, Tyson A., Korlach, Jonas, Pukkila, Patricia J., Aravind, L., Rao, Anjana
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4260599/
https://ncbi.nlm.nih.gov/pubmed/25406324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419513111
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