PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis

Aberrant phosphoinositide-3-kinase (PI3K), mitogen-activated protein kinase (MAPK) and WNT signalling are emerging as key events in the multistep nature of prostate tumourigenesis and progression. Here we report a compound prostate cancer murine model, in which these signalling pathways cooperate to...

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Pubblicato in:J Pathol
Autori principali: Jefferies, Matthew T., Cox, Adam C., Shorning, Boris Y., Meniel, Valerie, Griffiths, David, Kynaston, Howard G., Smalley, Matthew J., Clarke, Alan R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128396/
https://ncbi.nlm.nih.gov/pubmed/29134654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4977
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