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ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells

BACKGROUND: ERRα, a constitutive transcription factor that regulates energy metabolism, plays an important role in the progression of various tumours. However, its role in cell survival and proliferation and its implication in targeted therapy in colon cancer remains elusive. METHODS: The expression...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Zhou, Sheng, Xia, Hongwei, Xu, Huanji, Tang, Qiulin, Nie, Yongzhan, Gong, Qi yong, Bi, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125878/
https://ncbi.nlm.nih.gov/pubmed/30185207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0862-8
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