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Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer
Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management. Herein, we demonstrate how targeting SOAT1 promotes YAP ex...
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| Publicado no: | Cell Death Discov |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7910478/ https://ncbi.nlm.nih.gov/pubmed/33637695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00421-3 |
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