The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes

The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients. DNMT3A is active as tetramer and the R882H mutation is located in one of the subunit/subunit interfaces. Previous work has reported that formation of mixed wildtype/R882H complexes leads to a strong loss of catal...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Emperle, Max, Dukatz, Michael, Kunert, Stefan, Holzer, Katharina, Rajavelu, Arumugam, Jurkowska, Renata Z., Jeltsch, Albert
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125428/
https://ncbi.nlm.nih.gov/pubmed/30185810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31635-8
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